my best friend is screwing up her life--please help me.

My best friend is turning into a total burnout. I'm not against drugs and alcohol at all really, but I'm starting to worry about her. She is going through a lot of sh-- right now and she is drinking and using away her pain--but of course it always comes back. I told her it hurts to watch her go down this road--but it makes no difference. Every day she calls me when she's high and I cant talk to her like that. She's going to fu-- up her life and I'm scared for her. She's always smoking weed--I dont care about that though, its not that bad. But she's drinking a lot and she is getting shrooms and an assload of pills. I've had my share of drugs and sh-- so I dont want to sound hypocritical but I dont know what to do--will someone please help me?

Thanks for the suggestions. I'm still thinking what to do...